Risk Factors of Early and Late Onset Preeclampsia

Abstract

Objectives. Because early and late preeclampsia (PE) are thought to be different disease entities, our objective in this study to identify the differences in risk factors between early and late onset pre-eclampsia. Methods. A case series study was carried out involving 300 pregnancies with pre-eclampsia (123 early onset and 177 late onset) treated at Tripoli Medical Center, Libya, Tripoli between 1st January 2015 and 31st December 2015. The data were reviewed from antenatal and delivery records. Results. Factors were different between early and late onset of preeclampsia some of them were more significant to early onset and other more significant to late onset of preeclampsia and others were insignificant in onset of preeclampsia in our study. The risk factors that differ between early and late onset of pre-eclampsia were history of chronic hypertension to mother and history of high blood pressure in previous pregnancy, multiple pregnancy, maternal age ≥35 years were significant associated to early onset of preeclampsia while family history of chronic hypertension. Family history of diabetes mellitus, nulliparity and diabetic mother, maternal age <35 significant associated with late onset preeclampsia. Conclusions. These risk factors are of value to obstetricians in identifying patients at risk for pre-eclampsia and in implementing primary prevention.