Association of Gender, Age, Physiological, and Biochemical Parameters among Chronic Renal Failure Patients at Zawia Kidney Hospital

Abstract

Background and objectives. Chronic renal failure is a major problem and one of the main causes of morbidity and mortality in the world. kidneys maintain internal balance of water, salts and minerals by eliminating waste products from the body. This study conducted to evaluate the association of physiological and biochemical changes among patients with renal failure who undergo dialysis compared to healthy people. Also, to identify the incidence of CKD in males and females. Methods. This study was conducted from January 2020 to December 2020 at Zawia Kidney Hospital. It was including 114 patients with chronic renal failure and 75 healthy people. The biochemical variables which were examined in the blood serum include glucose, triglycerides and cholesterol, urea, creatinine, and electrolytes in patients with renal failure as well as the healthy people. Results. This study showed that patients aged over 31year had higher frequency of kidney failure. There was a statistically significant difference in the glucose levels between the patient’s group and the control group (p < 0.001) with patients having higher average glucose levels compared to the control group. There were no statistically significant differences between the two groups in cholesterol levels (p˂0.904). However, there was a statistically significant difference in triglyceride levels between patients and controls (p-value =0.021) as patients having higher levels compared to the control group. Statistically significant differences observed in urea, creatinine, calcium, sodium, potassium and phosphate values among renal failure and control groups as (p˂0.001 for each). In the relationship between blood type patients and kidney disease, the results showed a significant association between blood type and kidney failure (p<0.001). Also, our study revealed that there is a significant correlation between gender and chronic renal failure (p<0.001). In addition, an odds ratio of 11.7 indicates that the odds of men developing kidney failure are 11.7 times higher than that of women. Conclusion. Older ages, male, and O blood group are risk factors for chronic renal failure. Clear difference in the level of biochemical parameters in chronic renal failure compared to healthy people.